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KMID : 0359819960250050992
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Journal of Korean Neurosurgical Society
1996 Volume.25 No. 5 p.992 ~ p.995
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Antibiotic Concentrations of Cerebrospinal Fluid in Patients with Various Amount of Extraventricular Drainage during Intraventricular Infusion
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윤수한
안영환/안영민/조경기/김성환
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Abstract
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Phamacokinetic study of the antibiotic concentrations in the cerebrospinal fluid was done with high pressure liquid chromatography of CSF samples from twelve patients who had various amount of continuous extra ventricular drainage during
antibiotic
administration Five patients with large amount(over 150cc day) of drainage and decreased CSF antibiotic concentrations dramatically below the effective concentration within 4 hours after intraventricular antibiotic administration but six patients
with
small(less than 150cc day) drainage maintained CSF antibiotic level above effective concentration even 24 hours after administration. In conclusion repeated intraventricular administration of antibiotic is necessary to maintain the effective drug
level
in the patient with CSF drainage over 150cc/day.
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KEYWORD
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